Clinical efficacy and adverse effect of desloratadine citrate decremental therapy in treatment of chronic urticaria
10.3760/cma.j.issn.1008-6706.2016.01.018
- VernacularTitle:枸地氯雷他定递减疗法治疗慢性荨麻疹的临床疗效和不良反应分析
- Author:
Shoutian QIU
;
Xuehu DAI
;
Ming YAO
- Publication Type:Journal Article
- Keywords:
Urticaria;
Desloratadine citrate;
Dosing method
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;(1):62-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical efficacy and adverse reactions of desloratadine citrate decre-mental therapy in treatment of chronic urticaria.Methods 162 cases of patients with chronic urticaria were selected, they were randomly divided into observation group and control group.Control group was given routine treatment of desloratadine citrate capsule,while the observation group was given desloratadine citrate capsule decreasing therapy, the therapeutic effect and the levels of serum immunoglobulins were compared between the two groups.Results After treatment,the total effective rate of the observation group was 95.06%,there was no significant difference compared with 92.59% of the control group (χ2 =3.254,P >0.05);Two weeks and four weeks after treatment,IgE levels were significantly lower than before treatment,there were significant difference (t =8.291,7.931,6.936,5.152,all P <0.05),and the observation group change was more significant,the differences between the two groups were statistically significant (t =7.913,8.136,all P <0.05).After treatment symptom score was significantly lower than before treat-ment,and there were significant difference (t =7.519,8.015,all P <0.05),but the differences between groups were not significant (t =3.152,2.781,all P >0.05).The recurrence rate in the treatment group was 19.75%,which was significantly lower than the 40.74% of the control group,the difference between the two groups was statistically signif-icant (χ2 =6.914,P <0.05).But there was no significant difference in the incidence of adverse reactions between the two groups (χ2 =1.927,P >0.05).Conclusion Desloratadine citrate capsules in treatment of chronic urticaria can not only obtain more effective clinical curative effect,but also has less toxic side effect.For the purposes of the application method of the drug,decreasing method compared with conventional medication therapy can effectively improve the level of serum IgE.Therefore,it is worthy of clinical application.
