Effect of dexmedetomidine combined with sufentanil on postoperative analgesia, early postoperative cognitive function and serum inflammatory factors in patients with laparoscopic gastrectomy of gastric cancer
- VernacularTitle:右美托咪定联合舒芬太尼对腹腔镜胃癌切除患者术后镇痛作用、早期认知功能及对血清炎症因子水平影响研究
- Author:
Yibing WANG
;
Donghang CAO
;
Haifei XIANG
- Publication Type:Journal Article
- Keywords:
dexmedetomidine;
sufentanil;
analgesic effect;
inflammatory factor
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):67-69
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of dexmedetomidine combined with sufentanil on postoperative analgesia , early postoperative cognitive function and serum inflammatory factors in patients with laparoscopic gastrectomy of gastric cancer.Methods 80 cases of laparoscopic resection of gastric cancer were randomly assigned to treatment group and control group.The control group were treated by sufentanil 1.6μg/kg.The treatment group were given sufentanil 1.6μg/kg combined with dexmedetomidine 2 μg/kg.The analgesic effect, early cognitive function and serum levels of inflammatory factors were tested and compared after surgery.Results Compared with the control group, the VAS score in 4 h,8 h,24 h and 48 h after surgery were lower in the treatment group (P<0.05), the POCD(P<0.05), the IL-6,IL-10 and TNF-αlevel were lower in the treatment group(P<0.05). Conclusion Dexmedetomidine combined with sufentanil showes better postoperative analgesic effect and fast recovery of cognitive function, regulate the levels of serum inflammatory cytokines after laparoscopic resection of gastric cancer .
