Effect of eszopiclone combined with sertraline on serum S100βand clinical efficacy in patients with depression after cerebral infarction
- VernacularTitle:右佐匹克隆联合舍曲林对脑梗死后抑郁患者血清S100β的影响及其疗效研究
- Author:
Xuan ZHANG
;
Hua HONG
- Publication Type:Journal Article
- Keywords:
eszopiclone;
sertraline;
depression after cerebral infarction;
S100β;
clinical curative effect
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):76-78
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the effect of eszopiclone combined with sertraline on serum S100βand clinical efficacy in patients with depression after cerebral infarction.Methods 58 patients who were diagnosed with depression after cerebral infarction were collected.All patients were randomly divided into experimental group and control group,29 cases in each group.Patients in the control group received sertraline treatment, patients in the experimental group were given eszopiclone treatment on the basis of control group, after the treatment, the serum levels of S100β,BDNF and clinical efficacy were detected in all patients.Results After treatment, compared with control group, the serum level of S100βwas lower in the experimental group(P<0.05); the serum level of BDNF was higher in the experimental group(P<0.05); the total efficiency was higher in the experimental group (P<0.05).Conclusion The eszopiclone combined with sertraline can significantly reduce the serum level of S100β,and improve serum level of BDNF in patients with depression after cerebral infarction,improve the therapeutic effect.
