Effect of ShenQi FuZheng injection on peripheral blood AngⅡ, ET-1 levels and clinical curative effect in patients with congestive heart failure
- VernacularTitle:参芪扶正注射液对心衰患者外周血AngⅡ、ET－1影响及临床疗效研究
- Author:
Peng LIU
;
Xinya XU
;
Ning LI
- Publication Type:Journal Article
- Keywords:
ShenQi FuZheng injection;
congestive heart failure;
AngⅡ;
ET-1;
clinical curative effect
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):81-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis effect of ShenQi FuZheng injection on peripheral blood angiotensin II(AngⅡ), endothelin-1(ET-1) levels and clinical curative effect in patients with congestive heart failure.Methods 52 patients who were diagnosed with chronic heart failure were collected.All patients were randomly divided into experimental group and control group, 26 cases in each group.Patients in the control group received conventional western medicine treatment, patients in the experimental group were given ShenQi FuZheng injection on the basis of control group treatment, after the treatment, the plasma levels of AngⅡ and ET-1, cardiac function and clinical efficacy were detected in all patients.Results After treatment, compared with control group, the plasma levels of AngⅡ was lower in the experimental group(P<0.05);the plasma levels of ET-1 was lower in the experimental group(P<0.05); the LVEF,CO and SV levels were higher,and the LVED level was lower in the experimental group(P<0.05); the effective rate of patients in the experimental group was higher(P<0.05).Conclusion The ShenQi FuZheng injection can significantly reduce the plasma AngⅡand ET-1 levels in patients with congestive heart failure, improve heart function and clinical curative effect.
