Study on the effect of Longdanxiegan capsule on serum sVCAM-1, immune globulin and SOD level in patients with sudden deafness and tinnitus
- VernacularTitle:突发性耳聋、耳鸣患者应用龙胆泻肝胶囊对血清sVCAM－1、免疫球蛋白及SOD水平影响研究
- Author:
Zhaodong ZHANG
;
Shun WU
;
Zhaoyang ZHOU
;
Jing SHAO
;
Liyuan BAI
;
Zhiyong WANG
- Publication Type:Journal Article
- Keywords:
Longdanxiegan capsule;
sudden deafness;
Tinnitus;
sVCAM-1;
Immunoglobulin;
SOD
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):117-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis the effect of Longdanxiegan capsule on serum sVCAM-1, immune globulin and SOD level in patients with sudden deafness and tinnitus.Methods 48 patients who were diagnosed with sudden deafness and tinnitus were collected.All patients were randomly divided into experimental group and control group,24 cases in each group.Patients in the control group received conventional western medicine treatment, patients in the experimental group were given Erlongzuoci pill on the basis of control group treatment , after the treatment, the serum levels of sVCAM-1, IgG, IgA, IgM and SOD were detected in all patients.Results After treatment, compared with control group, the serum levels of sVCAM-1 was lower in the experimental group,and the difference was statistically significant(P<0.05);the serum IgG, IgA and IgM levels were lower in the experimental group (P<0.05); the serum SOD level was higher in the experimental group (P<0.05).Conclusion The Longdanxiegan capsule can reduce significantly the serum sVCAM-1, IgG, IgA and IgM levels, improve serum SOD level in patients with sudden deafness and tinnitus, improve immune function and the ability to remove free radicals , and have a guiding significance for clinica .
