Effect of Guizhi Fuling pills on levels of serum MAPK, ERK and VEGF in patients with endometriosis
- VernacularTitle:桂枝茯苓丸对子宫内膜异位症患者血清MAPK、ERK和VEGF水平影响研究
- Author:
Jing HAN
;
Wenying WU
- Publication Type:Journal Article
- Keywords:
Guizhi Fuling pills;
endometriosis;
MAPK;
ERK;
VEGF
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):125-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Guizhi Fuling pills on levels of serum MAPK, ERK and VEGF in patients with endometriosis. Methods 60 patients with endometriosis were selected and according to the random control table were divided into the experiment group and the control group, 30 cases each.The control group were treated with conventional acetate goserelin sustained-release implantation agent subcutaneous injection, the experiment group were treated by Guizhi Fuling pill treatment.After treatment, the clinical efficacy, serum MAPK, ERK-5, VEGF, ERK, T-cad and VE-cad levels of the patients were compared.Results Compared with the control group, the clinical total effective rate was higher in the experiment group (P<0.05);MAPK and ERK-5 levels in serum were lower (P<0.05), ERK level in serum was lower(P<0.05);T-cad and VE-cad levels in serum were lower(P<0.05);VEGF level in serum was lower(P<0.05).Conclusion Guizhi Fuling pill can block the cell signal transduction pathway through inhibition of MEK and ERK activity, thereby inhibit abnormal endometrial proliferation and cell division cycle, can effectively inhibit the proliferation and differentiation of the tumor.
