Targeting delivery nucleic acid into mammalian mitochondria
10.3969/j.issn.1001-1978.2016.01.001
- VernacularTitle:靶向哺乳动物细胞线粒体的核酸转运
- Author:
Ailing FU
- Publication Type:Journal Article
- Keywords:
mitochondrial transduction;
targeting sequence;
nucleic acid transfer;
mitochondria-associated diseases;
tRNA carrier;
5s rRNA transduction;
shuttle protein
- From:
Chinese Pharmacological Bulletin
2016;(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial DNA (mtDNA)genome mutations and defects are the essential mechanism of a various of mitochondrial dysfunction associated with diseases. The studies of targeting de-livery nucleic acid into mammalian mitochondria can thoroughly correct mtDNA mutation, rescue mtDNA impairment and then reverse the progress of diseases. There’s obvious differences be-tween nucleic acid import pathway of mammalian mitochondria and gene transfection of nuclei. In this paper, the effective strat-egies of delivering DNA and RNA(tRNA,rRNA,mRNA and an-tisense RNA)into mitochondria have been reviewed, as well as the challenges and development.
