Effect of tiotropium bromide applied in 45 cases patients with bronchiectasis accompanied by obstructive ventilation dysfunction
- VernacularTitle:45例支气管扩张伴阻塞性通气障碍患者应用噻托溴铵的效果
- Author:
Xuehuang FENG
;
Yong LIANG
;
Junxu XU
- Publication Type:Journal Article
- Keywords:
bronchiectasis;
obstructive ventilation dysfunction;
tiotropium bromide
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):150-152
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of tiotropium bromide in the treatment of patients with bronchiectasis accompanied by obstructive ventilation dysfunction.Methods 45 patients with bronchiectasis accompanied by obstructive ventilation dysfunction who were treated in the third people’s hospital of Haikou city from January 2014 to January 2015 were selected, and divided into control group (22 cases) and experimental group (23 cases) with the randomized controlled methods.The control group received routine treatment and experimental group received tiotropium bromide powder inhalation for a 8 week’s consecutive treatment.The pulmonary function, blood gas were compared and analyzed by BORG dyspnea score, six-minutes walk test (6MWT) and St.George’s respiratory questionnaire ( SGRQ).Results After treatment, maximal voluntary ventilation ( MVV) (%) in experimental group was significantly higher than that in control group(P<0.05), but there were no significant differences in forced expiratory volume in one second (FEV1), FEV1 (%), forced vital capacity ( FVC) (%) and FEV1/FVC between two groups.The PaCO2 in experimental group was significantly higher than that in control group ( P <0.05 ), but there was no significant difference in PaO2 between two groups.The 6MWD in experimental group was significantly higher and SGRQ values was lower than those in control group(P<0.05).Conclusion Long-term and regular usage of tiotropium bromide powder inhalation could improve pulmonary ventilation function and improve the quality of life of patients with bronchiectasis accompanied by obstructive ventilation dysfunction.
