Clinical efficacy of Shuxuening injection combined with epalrestat for diabetic nephropathy
- VernacularTitle:舒血宁联合依帕司他治疗糖尿病肾病的临床疗效
- Author:
Jingwen LIU
;
Yimei TIAN
;
Yan ZHONG
;
Rongjing YANG
;
Liming CHEN
- Publication Type:Journal Article
- Keywords:
Shuxuening injection;
epalrestat;
diabetic nephropathy;
combination
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):155-157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of Shuxuening combined with epalrestat in the treatment of diabetic nephropathy. Methods Eighty patients from March 2014 to June 2015 in Metabolic Disease Department of the Second Hospital of Tianjin were randomly divided into observation group and control group with 40 patients in each group.The control group received epalrestat, and the observation group received Shuxuening injection on the baisis of control group. The related indicators were compared between two groups.Results After treatment, the 24 h-urine microalbumin, plasma low density lipoprotein and serum creatinine in observation group [(239.31 ±106.54)mg/L,(2.45 ±0.55)mmol/L,(95.54 ± 22.13)mol/L]were lower than those in control group [(349.90 ±148.40),(3.41 ±0.52),(108.76 ±34.30)](P<0.05).The β2-microglobulin (β2-MG) and plasma high-sensitive C-reactive protein (hs-CRP) in observation group [(0.39 ±0.06),(6.31 ±1.58)mg/L]were lower than those in control group [(0.49 ±0.12),(7.89 ±1.35)](P<0.05).The total efficacy in observation group was higher than that in control group (70.0%vs.45.0%,P<0.05).Conclusion Shuxuening injection joint epalrestat has the exact efficacy in treatment of patients with diabetic nephropathy.
