DJ-1 regulates the function of mitochondria in Parkinson’s disease
10.3969/j.issn.1001-1978.2016.01.006
- VernacularTitle:DJ-1蛋白对线粒体的功能调节在帕金森病中的作用
- Author:
Yongfei GUO
;
Yi SUN
;
Xin ZHAO
;
Xiaoping PU
- Publication Type:Journal Article
- Keywords:
DJ-1;
mitochondria;
Parkinson’ s disease;
mito-chondrial complex I;
mitophagy;
oxidative stress;
mitochondrial homeostasis
- From:
Chinese Pharmacological Bulletin
2016;(1):22-26
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial dysfunction plays an important role in the process of PD, DJ-1 participates in regulating the function of mitochondria,which has an effect on the protection of mitochon-dria. DJ-1 mutations can lead to the decrease of the activity of mitochondrial complex Ⅰ, the decrease of mitochondrial mem-brane potential and then mitochondrial fragmention and mitoph-agy, and then further damage neurons and trigger PD. This re-view presents the role of DJ-1 in regulating the function of the mitochondria in the pathogenesis of Parkinson's disease(PD).
