Inhibitory effect of IL-37 on inflammation-related diseases
10.3969.j.issn.1671-7856.2015.12.015
- VernacularTitle:IL－37对炎症相关性疾病的抑制作用
- Author:
Mengyuan LI
;
Xingjiu YANG
;
Ran GAO
;
Damo XU
- Publication Type:Journal Article
- Keywords:
IL-37;
Anti-inflammatory cytokine;
Inflammation-related diseases
- From:
Chinese Journal of Comparative Medicine
2015;(12):75-80
- CountryChina
- Language:Chinese
-
Abstract:
Inteleukin-37 is a member of IL-1 family and originally named as IL-1F7.It has five different subtypes (IL-37a-e).It has been reported that IL-37 suppresses pro-inflammatory cytokines production of a variety of immune cells, and further regulate innate immune response. In addition, IL-37 has protective effects on colitis, arthritis, pancreatitis and other inflammatory diseases that induced by exogenous stimuli. In a word, IL-37 is a novel anti-inflammatory cytokine and plays an important role in a variety of inflammation-related diseases.
