Genetic controls of Th17 cell differentiation and plasticity.
10.3858/emm.2011.43.1.007
- Author:
Chen DONG
1
Author Information
1. Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX, USA. cdong@mdanderson.org
- Publication Type:Review
- Keywords:
CD4-positive T-lymphocytes;
cell differentiation;
cytokines;
Th17 cells;
transcription factors
- MeSH:
Animals;
CD4-Positive T-Lymphocytes/cytology/*immunology;
Cell Differentiation;
Cell Lineage;
Cytokines/*genetics;
Epigenesis, Genetic;
Gene Expression Regulation;
Humans;
Interleukin-17/immunology/metabolism;
T-Lymphocytes, Regulatory;
Th1 Cells/immunology;
Th17 Cells/*immunology;
Th2 Cells/immunology;
Transcription Factors/*genetics;
Transcription, Genetic
- From:Experimental & Molecular Medicine
2011;43(1):1-6
- CountryRepublic of Korea
- Language:English
-
Abstract:
CD4+ T lymphocytes play a major role in regulation of adaptive immunity. Upon activation, naive T cells differentiate into different functional subsets. In addition to the classical Th1 and Th2 cells, several novel effector T cell subsets have been recently identified, including Th17 cells. There has been rapid progress in characterizing the development and function of Th17 cells. Here I summarize and discuss on the genetic controls of their differentiation and emerging evidence on their plasticity. This information may benefit understanding and treating immune diseases.
