Study on gene polymorphism in patients with aspirin resistance
- VernacularTitle:阿司匹林抵抗患者的基因多态性研究
- Author:
Zhouliang SUN
;
Junting JIA
;
Huiling XIAO
- Publication Type:Journal Article
- Keywords:
COX-1;
P2Y1;
GPIa;
GPIIIa;
gene polymorphism;
aspirin resistance;
correlation
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):42-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between aspirin resistance and COX-1, P2Y1, GPIa and GPIIIa gene polymorphism. Methods 35 case with aspirin resistant were selected and were given aspirin enteric coated tablets for oral treatment, 14 days.After the determination COX-1, P2Y1 and GPIa and GpIIIa gene polymorphism of each patient were analysis.Results The genotype AA of COX1 (A-842G) locus and CC of COX1 (C50T) locus was higher than other genotype (P<0.05);AG of P2Y1 (A1622G) locus genotype and CC of P2Y1 (C893T) locus genotype was higher than other genotype (P<0.05);CT of GPIa (C807T) locus genotype and GA of GPIa (G873A) locus genotype was higher than other genotype (P<0.05);PLA1/A1 of GPⅢa(T1565C)locus genotype was higher than other genotype (P<0.05).Conclusion P2Y1 (C893T), GPIa (C807T) allele is associated with aspirin resistance,With COX-1 (A-842G, C50T), GPIa (G873A), GP III A (T1565C), P2Y1 (A1622G) allele is more likely to induce the occurrence of aspirin resistance.
