Effect of Tianma Gouteng Decoction on index of heart function and major cardiovascular events in treatment of H-type hypertension patients with left ventricular hypertrophy
- VernacularTitle:天麻钩藤饮对H型高血压左室肥厚患者心功能指标及主要心血管事件的影响
- Author:
Juan LI
;
Wei WEN
;
Fang WANG
- Publication Type:Journal Article
- Keywords:
Tianma Gouteing Decoction;
H-type hypertension;
left ventricular hypertrophy;
cardiac function;
cardiovascular events
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):56-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of index of heart function and major cardiovascular events (nonfatal myocardial infarction, stroke, and cardiovascular death) to H-type hypertension patients with left ventricular hypertrophy caused by Tianma Gouteng Decoction.Methods 126 H-type hypertension patients with left ventricular hypertrophy from January 2014 to May 2014 in our hospital were divided into observation group and control group,63 cases in each group.Control group was treated with conventional western medicine, observation group was treated with Tianma Gouteng Decoction on the basis of control group.The levels of plasma homocysteine (Hcy), left ventricular ejection fraction (LVEF),the E/A, and the incidence of major cardiovascular events were recorded and compared between the two groups.Results Compared with pre-treatment, the levels of Hcy in the two groups were significantly decreased(P<0.05), and the effect of observation group was better (P<0.05).After the treatment, the E/A and LVEF of the two groups were significantly improved (P<0.05); the E/A ratio and LVEF in observation group were significantly higher than those in control group (P<0.05).The incidence of major cardiovascular events in observation group was significantly lower than that in control group (6.35%VS 19.05%,P<0.05).Conclusion Tianma Gouteng Decoction can significantly reduce the Hcy of patients who get H-type hypertension, improve diastolic and systolic function and lower the occurrence of major cardiovascular events.
