Effect of adefovir dipivoxil combined with pegylated interferon on serum Th1/Th2 type cytokines and IgM and IgG antibodies in patients with hepatitis B
- VernacularTitle:阿德福韦酯片联合聚乙二醇干扰素对乙型肝炎患者血清Th1／Th2型细胞因子及IgM与IgG抗体影响研究
- Author:
Jiantao LIU
;
Xu ZHANG
- Publication Type:Journal Article
- Keywords:
adefovir dipivoxil;
pegylated interferon;
hepatitis B;
Th1/Th2 type cytokines;
IgM;
IgG
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):73-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse effect of adefovir dipivoxil combined with pegylated interferon on serum Th1/Th2 type cytokines and IgM and IgG antibodies in patients with hepatitis B.Methods 52 patients who were diagnosed with chronic hepatitis B in Qian’an Infectious Disease Hospital were collected.All patients were randomly divided into experimental group and control group,26 cases in each group.Patients in control group received treatment with adefovir dipivoxil , patients in experimental group were given pegylated interferon treatment on the basis of control group treatment , after treatment, the serum levels of IFN-γ,IL-4,IgM and IgG were detected in all patients .Results After treatment, compared with control group , the serum level of IFN-γwas higher in experimental group(P<0.05); the serum level of IL-4 was lower in experimental group(P<0.05); the serum level of IgM and IgG were lower in experimental group (P<0.05).Conclusion Adefovir dipivoxil combined with pegylated interferon can significantly reduce the serum levels of IL-4,IgM and IgG, and improve the serum level of IFN-γin patients with hepatitis B , reverse Th1/Th2 imbalance .
