Effect of spironolactone combined with valsartan on renal function in patients with early diabetic nephropathy
- VernacularTitle:螺内酯与缬沙坦联合应用对早期糖尿病肾病患者肾功能的影响
- Author:
Bin WU
;
Jing YING
- Publication Type:Journal Article
- Keywords:
spironolactone;
valsartan;
diabetic nephropathy;
renal function
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):89-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of spironolactone combined with valsartan on renal function in patients with early diabetic nephropathy.Methods 158 early diabetic nephropathy patients from May 2014 to June 2015 in department of endocrinology of Nanxun People’s Hospital of Huzhou were selected and divided into control group (79 cases) and experimental group (79 cases).The control group were treated by valsartan and the experimental group were treated with spironolactone on the basis of control group.The changes of renal function, potassium ion and blood rheology were observed and compared after treatment.Results Compared with control group post-treatment, the systolic pressure and diastolic pressure levels were lower, plasma urinary albumin excretion rates (UAER) level was lower (P <0.05), albumin (Alb), serum creatinine (Scr), blood urea nitrogen ( BUN) , creatinine clearance ( Ccr) and K +levels had no significant differences, whole blood specific viscosity, plasma specific viscosity and whole blood specific reduced viscosity were lower ( P <0.05 ) in experimental group.Conclusion Spironolactone combined with valsartan could effectively improve clinical efficacy of patients with early diabetic nephropathy , improve the renal function of patients, recover ion disorder and reduce blood viscosity.
