Study on the effect of salbutamol combined with noninvasive ventilator on TNF-α, IL-6, IL-8 and serum CK-MB activity in patients with chronic obstructive pulmonary disease with respiratory failure
- VernacularTitle:沙丁胺醇联合无创呼吸机对慢性阻塞性肺病合并呼吸衰竭患者TNF－α、IL－6、IL－8及血清CK－MB活性影响研究
- Author:
Yizhao LIN
;
Fang WANG
;
Rongzhao ZHANG
;
Songqing WEI
- Publication Type:Journal Article
- Keywords:
salbutamol;
noninvasive ventilation;
chronic obstructive pulmonary disease with respiratory failure;
TNF-α;
IL-6;
IL-8;
CK-MB
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):136-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis the effect of salbutamol combined with noninvasive ventilator on TNF-α,IL-6,IL-8 and serum CK-MB activity in patients with chronic obstructive pulmonary disease with respiratory failure.Methods 60 patients who were diagnosed with chronic obstructive pulmonary disease with respiratory failure were collected.All patients were randomly divided into experimental group and control group,30 cases in each group. Patients in the control group received noninvasive ventilator treatment, patients in the experimental group were given salbutamol treatment on the basis of control group treatment, after the treatment, the serum levels of TNF-α,IL-6,IL-8 and serum CK-MB activity were detected in all patients.Results After treatment, compared with control group, the serum level of TNFαwas lower in the experimental group,and the difference was statistically significant(P<0.05); the serum level of IL-6 and IL-8 were lower in the experimental group(P<0.05); the serum CK-MB activity was lower in the experimental group(P<0.05).Conclusion The salbutamol combined with noninvasive ventilator can significantly reduce the serum levels of TNF-α, IL-6, IL-8 and serum CK-MB activity in patients with chronic obstructive pulmonary disease with respiratory failure, reduce the inflammatory reaction and reduce the myocardial damage,and have a guiding significance for clinica.
