Efficacy of edaravone combined with clopidogrel on patients with acute cerebral infarction
- VernacularTitle:依达拉奉联合氯吡格雷治疗急性脑梗死患者的效果
- Author:
Huadong HUANG
;
Weihong SHI
;
Donghui LI
;
Hua ZHANG
- Publication Type:Journal Article
- Keywords:
edaravone;
clopidogrel;
combination therapy;
acute cerebral infarction
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):158-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of edaravone combine with clopidogrel on patients with acute cerebral infarction . Methods Eighty cases diagnosed with acute cerebral infarction from February 2014 to February 2015 were randomly divided into observation group and control group with 40 cases in each group.Control group received basic treatment of clopidogrel, observation group received edaravone on the basis of control group.The serum levels of superoxide dismutase ( SOD ) and malondialdehyde ( MDA ) between two groups were compared post-treatment. Results The serum SOD levels in observation group on 7th and 14th day post-treatment [(89.37 ±6.07, 99.14 ±11.24)U/mL]were significantly higher than those in control group [(71.26 ±7.43,80.01 ±12.02)U/mL](P<0.05).The serum MDA levels in observation group on 7th and 14th day post-treatment [(5.23 ±0.81, 3.42 ±0.48)nmol/mL]were significantly higher than those in control group[(7.16 ±1.01,5.24 ±0.71) nmol/mL](P<0.05).Conclusion Edaravone combined with clopidogrel has the exact effect in treatment of patients with acute cerebral infarction.
