Effects of Liraglutide on Omentin-1 and Insulin Resistance in High-fat Diet Obese Rats
- VernacularTitle:利拉鲁肽对高脂饮食诱导的肥胖大鼠血清网膜素1及胰岛素抵抗的影响
- Author:
Linna SUO
;
Wei WANG
- Publication Type:Journal Article
- Keywords:
liraglutide;
obese;
omentin-1;
insulin resistance
- From:
Journal of China Medical University
2015;(12):1129-1131
- CountryChina
- Language:Chinese
-
Abstract:
Objective to investigate the effects of liraglutide on omentin-1 and insulin resistance in high-fat diet rats. Methods Forty male Wi-star rats were randomly divided into four groups,and respectively fed with normal diet(NC group),high-fat diet(HF group),high-fat diet with small doses of liraglutide injected intraperitoneally(HF+Lira 1 group),and high-fat diet with large doses of liraglutide injected intraperitoneally (HF+Lira 2 group). After 16 weeks,the body weight,serum lipid levels,omentin-1 and insulin were measured,and then the insulin resistance in-dex were calculated. Results the body weight,the levels of tG,and the insulin resistance index in HF group were higher than NC group,omentin-1 was lower,and the differences were statistically significant(P < 0.05). tC,LDL-C were elevated,HDL-C was reduced,but there were no statisti-cally differences(P > 0.05). Compared with HF group,the body weight,the levels of tG,and the insulin resistance index in HF+Lira 1 group and HF+Lira 2 group were lower,omentin-1 was higher,the differences were statistically significant(P < 0.05). Furthermore,the effects of HF+Lira 2 group were more pronounced. Conclusion Liraglutide can restrain high-fat diet induced obesity,and improve insulin resistance through elevated the level of omentin-1 in dose-dependent manner.
