Research progress of bone morphogenetic proteins-9 induced periodontal ligament stem cells osteogenesis differentiation and it′s signal pathway
10.16571/j.cnki.1008-8199.2015.12.021
- VernacularTitle:骨形态发生蛋白-9诱导牙周膜干细胞成骨分化及信号通路的研究进展
- Author:
Pei WANG
;
Zhizhong CAO
- Publication Type:Journal Article
- Keywords:
BMP9;
PDLSCs;
Osteogenesis differentiation;
Smad signaling pathway;
p38MAPK signaling pathway
- From:
Journal of Medical Postgraduates
2015;(12):1327-1332
- CountryChina
- Language:Chinese
-
Abstract:
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β(TGF-β) superfamily and play critical roles in skeletal development, bone formation and stem cell differentiation.BMP9 is one of the most osteogenic BMPs, promoting osteogenesis differentiation of periodontal ligament stem cells ( PDLSCs) both in vitro and in vivo.Recently, signal transduc-tion studies have revealed that BMP-Receptor-Smads and BMP-Receptor-Mitogen activated protein kinase ( MAPK) play vital roles in BMP9 which promote PDLSCs osteogenesis differentiation.Several studies revealed that transcription factors closely associated with os-teogenesis differentiation are found in the downstream of the Smads and MAPK pathways.This review aims to summarize our current knowledge of BMP9-mediated osteogenesis by presenting recently completed works which may help us to further elucidate these path-ways.
