Antitumor effect of Ganoderma(Lingzhi) mediated by immunological mechanism and its clinical application
10.3867/j.issn.1000-3002.2015.06.001
- VernacularTitle:灵芝抗肿瘤作用的免疫学机制及其临床应用
- Author:
Zhibin LIN
- Publication Type:Journal Article
- Keywords:
Ganoderma;
polysaccharides;
tumor;
antineoplastic agents,phytogenic;
tumor escape;
therapeutic uses
- From:
Chinese Journal of Pharmacology and Toxicology
2015;(6):865-882
- CountryChina
- Language:Chinese
-
Abstract:
The anti-tumor effect of Ganoderma(Lingzhi) is closely related to immunoregulation. Based on our research and other references,this article discussed the antitumor effect of Ganoderma mediated by immunological mechanism, including promoting the function of mononuclear-macro?phages,and natural killers,promoting maturation and differentiation of dendritic cells,increasing its antigen presentation,activating lymphocytes and increasing cytotoxicity of cytotoxin T lymphocyte, promoting production of cytokines,inhibiting tumor escape from immune surveillance. Also, clinical studies with immunological indexes were reviewed.
