Research methods of ″18 incompatible medicaments″incompatibilitytoxicitycharacterizationoftraditional Chinese medicine based on early evaluation of overall toxicity
10.3867/j.issn.1000-3002.2015.06.013
- VernacularTitle:基于毒性整体早期评价的“十八反”中药配伍禁忌毒性表征的研究思路及方法
- Author:
Yubo LI
;
Liang JU
;
Haoyue DENG
;
Zhenzhu ZHANG
;
Lei WANG
;
Zhiguo HOU
;
Jia YIN
;
Yanjun ZHANG
- Publication Type:Journal Article
- Keywords:
18 incompatible medicaments;
drugs,Chinese herbal;
drug incompatibility;
early toxicity;
metabolomics;
biomarkers
- From:
Chinese Journal of Pharmacology and Toxicology
2015;(6):960-966
- CountryChina
- Language:Chinese
-
Abstract:
Currently,the toxicity study of traditional Chinese medicine is faced with the following problems. Firstly,the evaluation in vitro cannot fully reflect the true state of the body. Secondly,the traditional method is not sensitive enough to the early toxicity. Lastly,the toxicity evaluation indexes cannot determine whether the compatibility of traditional Chinese medicine produces toxicity or increases toxicity systematically. The paper proposed a synthesized early evaluation research method for target organ toxicity induced by traditional Chinese medicine:screening,validation,optimization and application. This method mainly inoolves early target organ toxicity biomarkers in screening,optimi?zation,validation,biological significance explanation,and application to the traditional Chinese medicine incompatibility based on the metabolic dynamic fingerprint spectrum in order to obtain biomarkers of target organ toxicity that are sensitive and precede conventional biochemical indices for early evaluation . We attempted to analyze the pattern of chang of the biomarkers for animals acted by″18 incompatible medicaments″compatibility combination. We found that Radix Aconiti Lateralis Preparata with cardiotoxicity were compatible with Rhizoma Pinelliae,and that Trichosanthes kirilowii Maxim,Fritillaria,Ampelopsis Radix and Bletilla striata without non-cardiotoxicity produced and increased cardiotoxicity systematically.
