Application of pregnane X receptor′s regulation of induction of cytochrome P-450 CYP3A to incompatibility of traditional Chinese medicine and toxicity predetermination
10.3867/j.issn.1000-3002.2015.06.014
- VernacularTitle:孕烷X受体对细胞色素P450 CYP3A基因表达的调控在中药配伍禁忌及中药毒性早期预测中的应用
- Author:
Han LI
;
Yuguang WANG
;
Yue GAO
- Publication Type:Journal Article
- Keywords:
drugs,Chinese herbal;
drug incompatibility;
drug toxicity predetermination;
cytochrome P-450 CYP3A;
pregnane X receptor;
drug metabolism
- From:
Chinese Journal of Pharmacology and Toxicology
2015;(6):967-972
- CountryChina
- Language:Chinese
-
Abstract:
The incompatibility of traditional Chinese medicine is an important part of traditional Chinese medicine compatibility theory,while early toxicity predetermination of traditional Chinese medi?cine is an important component of drug safety evaluation. Once a simple and reliable method to predict the compatibility of Chinese medicine and Chinese traditional medicine is established,it is possible to obtain the data of toxic reaction of Chinese herbal medicine quickly and early. Pregnane X receptor (PXR)is a ligand dependent transcription factor,acting as a ligand or activator of a large number of clinical drugs and of cytochrome P-450 CYP3A (CYP3A) gene expression induced by PXR. In the course of treatment of diseases,the activation of PXR may increase the risk of drug interactions and adverse reactions,resulting in decreased efficacy and even toxicity. This paper may provide a new method of drug toxicity predetermination depending on the PXR-CYP3A pathway.
