Preparation and dissolution rate determination of oridonin solid dispersion
10.16571/j.cnki.1008-8199.2015.12.016
- VernacularTitle:冬凌草甲素固体分散体的制备及溶出度测定
- Author:
Qingming ZHANG
;
Yunyan XU
;
Ping ZHANG
;
Hua SU
- Publication Type:Journal Article
- Keywords:
Oridonin;
Poloxamer;
Solid dispersion;
Dissolution rate
- From:
Journal of Medical Postgraduates
2015;(12):1303-1306
- CountryChina
- Language:Chinese
-
Abstract:
Objective Oridonin is a poorly water soluble drug with low bioavailability.The study aimed to prepared improve the dissolution rate of oridonin by preparation of oridonin solid dispersion with poloxamer. Methods The oridonin solid dispersion was prepared by dissolvent method with poloxamer188 as the carrier and determined by DSC and powder X-ray diffraction.The dissolu-tion rates in different pH dissolution mediums of pure drug, physical mixture and solid dispersion were determined by HPLC method. Results Oridonin exists as an amorphous state in the solid dispersion.Compared with the pure drug and physical mixture, the orido-nin solid dispersion was improved greatly without the pH influence on the drug release.The dissolution rate of oridonin solid dispersion in water, pH 6.8 PBS and pH 1.2 HCl were (92.6 ±4.2)%, (93.1 ±3.5)%and (94.4 ±2.9)% respectively. Conclusion Taking inpoloxamer188 as the carrier, the oridonin solid dispersion has successfully developed its dissolution rate.
