Clinical Characteristics and Evaluation in Dengue Fever Patients Combining Cardiac Involvement
10.3969/j.issn.1000-3614.2015.12.015
- VernacularTitle:登革热合并心脏受累的临床特征分析与评估
- Author:
Fanliang KONG
;
Qiang ZHAO
;
Tongguo WU
- Publication Type:Journal Article
- Keywords:
Dengue fever;
Cardiamyopathies;
Diagnosis
- From:
Chinese Circulation Journal
2015;(12):1195-1199
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To understand the cardiac involvement of Dengue fever patients and to analyze the clinical characteristics of Dengue fever combining cardiac complications.
Methods: A total of 395 patients of Dengue fever treated in our hospital were analyzed. Blood levels of CK, CK-MB, CTnT, NT-proBNP were examined, ECG and echocardiography (UCG) were conducted in all patients. Upon Dengue recovery, the levels of CK and CK-MB were re-examined in patients with elevated indexes.
Results: Overall, there were 47.3% patients with increased CK, 61.3% with increased CK-MB, 42.5% with increased CTnT and 22.4% with increased NT-proBNP; 37.2% patients with abnormal ECG and 29.9% with abnormal UCG. There were 65.5% patients showing CK and CK-MB reduction more than 4 days upon Dengue recovery. Compared to those without the history of heart disease (HD), the patients with HD history had the higher abnormal rates of CTnT (17.7 vs 60.8) %, NT-proBNP (4 vs 32.3) % and ECG (25.1 vs 51.7) %, UCG (15.7 vs 41.7) %, allP<0.01. The abnormal rates in patients with heart failure (HF) were higher than those without HF as in CK-MB (75.8 vs 53.2) %, cTnT (85.5 vs 31.7) % and ECG (87.1 vs 31.7) %, UCG (63.8 vs 17.0) %, allP<0.01. The abnormal rates in elder patients were higher than non-elder patients as in CTnT (64.4 vs 7.7) %, NT-proBNP (32.2 vs 4.9) % and ECG (53.4 vs 21.8) %, UCG (38.9 vs 14.1) %, allP<0.01. The patients with elder age and HD history were more likely to have cardiac involvement upon Dengue infection.
Conclusion: Blood levels of CK, CK-MB, CTnT, NT-proBNP and ECG, UCG could be used to evaluate the patients with Dengue fever in order to prevent the cardiac complications at the early stage.
