The incidence and risk factors of hyperuricemia after liver transplantation：a single-center retrospective study
10.3760/cma.j.issn.1674-6090.2015.06.014
- VernacularTitle:肝移植后高尿酸血症的发生率和相关危险因素分析：单中心回顾性研究
- Author:
Weiping RAO
;
Yujian NIU
;
Hongyu WANG
;
Chun XU
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Posttransplant hyperuricemia;
Serum creatinine;
Calcineurin inhibitors
- From:
Chinese Journal of Endocrine Surgery
2015;(6):493-496
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the incidence and related risk factors of hyperuricemia after liver transplantation.Methods A total of 286 cases undergoing liver transplantation from 2009 to 2012 in the Armed Police General Hospital , who had normal uric acid before transplantation and had been followed up for more than 1 year, were enrolled in this study.The clinical data, including liver and kidney function , blood glucose, and lipids were collected .The potential risk factors of hyperuricemia were analyzed .Results 53.5% cases ( 153/286)had hyperuricemia after transplantation.Hyperuricemic patients were predominately older (P =0.038). They also had a higher prevalence of increasing creatinine (P=0.000),and hyperlipidemia(P=0.000).Among female cases, hyperuricemic patients had a higher average BMI (P=0.027).Hyperuricemia group had an elevat-ed ratio of blood lipids 60.1%(92/153), higher than normal uric acid group (39.1%,52/133) ( P<0.05). Conclusions Liver transplantation recipients have a higher incidence of hyperuricemia , particularly in elderly and overweight female patients .Our findings suggest that postoperative hyperuricemia may be associated with high serum creatinine, elevated blood lipids.We should strengthen follow-up, take early detection and early treat-ment.
