Effects ofα-lipoic acid combined with motilin in treatment of patients with diabetic gastroparesis
10.3760/cma.j.issn.1674-6090.2015.06.015
- VernacularTitle:α-硫辛酸联合莫沙必利治疗糖尿病胃轻瘫的临床疗效
- Author:
Yingying PAN
- Publication Type:Journal Article
- Keywords:
α-lipoic acid;
Motilin;
Diabetic gastroparesis;
Gastrointestinal dynamics;
Gastroin-testinal hormone
- From:
Chinese Journal of Endocrine Surgery
2015;(6):497-500
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the curative effects and safety of α-lipoic acid combined with motilin in treatment of patients with diabetic gastroparesis and its influence on gastrointestinal dynamics and gastrointesti -nal hormone.Methods 108 patients with diabetic gastroparesis were included and they were divided into the ob -servation group and the control group according to the random indicator method , with 54 cases in each group .All patients were given routine hypoglycemic therapy .On this basis, patients in the control group were given motilin while patients in the observation group were given α-lipoic acid combined with motilin .After 14 days, the cura-tive effects, the rate of gastric emptying, oral-colonic transit time(OCTT), and gastrointestinal hormone including gastric dynamic element ( MTL ) and somatostatin ( SS ) , stomach gastrin-releasing ( GAS ) and adverse reactions during treatment were compared between the 2 groups.Results The total effective rate was 85.19% and 64.81% respectively in the observation group and the control group , and the difference had statistical significance (P<0.05).Compared with those before treatment , gastric emptying rate in the 2 groups were significantly in-creased after treatment , and OCTT were significantly extended .The difference had statistical significance ( P<0.05).Compared with those before treatment , MTL and GAS in the 2 groups were significantly decreased while SS were significantly increased.The difference had statistical significance(P<0.05).The changes of MTL, SS, and GAS were more obvious in the observation group than in the control group , and the difference had statistical significance ( P<0.05 ) .The incidence of adverse reactions in the observation group was 11.11% and it was 7.41%in the control group.The difference had no statistical significance (P>0.05).Conclusions The cura-tive effects of α-lipoic acid combined with motilin in treatment of diabetic gastroparesis is distinct .Its mechanism may be related to improving gastrointestinal disorders , and adjusting gastrointestinal hormone .
