Chemotherapy combined with immunotherapy in treatment of middle and advanced stage non-small cell lung cancer
10.3760/cma.j.issn.1674-6090.2015.06.017
- VernacularTitle:化疗联合免疫活性细胞治疗中晚期非小细胞肺癌的疗效观察
- Author:
Jiangang ZHANG
;
Zhifeng YE
;
Ling HUANG
;
Ting HUANG
;
Zhidi ZHANG
- Publication Type:Journal Article
- Keywords:
Chemotherapy;
Immunotherapy;
Non-small cell lung cancer
- From:
Chinese Journal of Endocrine Surgery
2015;(6):504-507
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy of chemotherapy combined with immunotherapy in treatment of middle and advanced stage non-small cell lung cancer and improvement of patients'life quality.Methods 140 patients with middle and advanced stage non-small cell lung cancer treated from Mar .2012 to Mar.2014 were in-cluded and they were randomly divided into two groups:the observation group(70 cases)and the control group(70 cases).The observation group took chemotherapy combined with immunotherapy , while the control group took chemotherapy treatment alone .Patients'life quality , treatment effects and changes in immune indexes were co-mared between the two groups .Results The improvement rate of life quality of the observation group (90.0%) was significantly higher than that of the control group (58.6%), and the difference had satistical significance (P<0.05).The response rate of the observation group (88.6%) was significantly higher than that of the control group(70.0%), and the difference had statistical significance (P<0.05).The increasement rate of CD3 +, CD4 +, CD8 +cells, as well as CD4 +/CD8 +cells was significantly higher in the observation group than in the control group, and the difference had statistical significance (P<0.05).Conclusion Chemotherapy combined with immunotherapy in teatment of patients with middle and advanced non-small cell lung cancer has obvious effect, high safety, and high clinical value .
