The clinical value of HSP27 expression of bone marrow mononuclear cells in multiple myeloma
10.3969/j.issn.1671-8348.2015.35.015
- VernacularTitle:骨髓单个核细胞热休克蛋白27表达在多发性骨髓瘤中的临床价值
- Author:
Qing WANG
;
Meifang ZHANG
;
Xiaoli GUO
;
Lianghong WANG
;
Jun SONG
;
Bin YUAN
;
Chi CHEN
;
Pengxiang GUO
;
Hongqian ZHU
- Publication Type:Journal Article
- Keywords:
multiple myeloma;
heat-shock proteins;
prognosis;
treatment response
- From:
Chongqing Medicine
2015;(35):4946-4949
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of HSP27 expression with treatment response ,remission rate ,prognosis in multiple myeloma(MM) patients .Methods Eighty‐six patients with MM first diagnosis and 27 relapse cases were collected re‐spectively .Control was defined as non‐hematological malignance .The MM patients divided into first diagnosis ,relapse conventional chemotherapy group and bortezomib group .HSP27 expression and protein level were measured on pre‐and post 1 ,2 and 3 treatment circles .Results The tendency of HSP expression and protein level:relapse‐MM patients> first‐diagnosis MM patients> control . HSP27 expression and level in Ⅲ phase was higher than those in Ⅱ phase for first‐diagnosis MM patients .Bortizomib‐containing chemotherapy protocol showed more effectively decrease on HSP27 than chemotherapy treatment only .At post‐1 treatment circle , HSP27<1 showed higher survival rate than HSP27>1 and delayed the relapse time .Conclusion BMMNC‐HSP27 expression and protein level is associated with staging ,treatment response and prognosis in MM patients .
