Efficacy andβcell function improvement of Linagliptin in combination with Metformin in newly diagnosed T2DM patients
10.3969/j.issn.1006-6187.2015.12.005
- VernacularTitle:新诊断2型糖尿病患者利格列汀联合口服药降糖的疗效及对胰岛β细胞功能改善的临床观察
- Author:
Yujie LI
;
Hongchen CUI
;
Chengjun SUN
- Publication Type:Journal Article
- Keywords:
Linagliptin;
Metformin;
Diabetes mellitus,type 2;
Clinical effect
- From:
Chinese Journal of Diabetes
2015;(12):1073-1076
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy and safety of Linagliptin in combination with Metformin in newly diagnosed T2DM patients. Methods A total of 140 newly diagnosed T2DM patients were enrolled in this study. All the patients were admitted in the Endocrinology and Metabolism department of our hospital from January 2013 to October 2013. Random number table method was used in patients’ selection. All the patients were divided into two groups :Linagliptin plus Metformin group (Linagliptin group ,n=70) and Glipizide plus Metformin group (Glipizide group ,n=70) ,and followed up for 12 weeks. Efficacy and safety of treatment were compared between the two groups. Results The difference of FPG ,2 hPG and HbA1 c did not reach the statistical significance between the two groups at baseline treatment (P>0.05). FPG ,2 hPG and HbA1 c were significantly lower after treatment compared with baseline in both groups (P<0.05). FC-P ,2 hC-P ,HOMA-β,HOMA-IR ,IAI and adiponectin level at baseline were similar between the two groups ( P> 0.05 ). All these indicators were improved after treatment in both groups (P< 0.05) ,and were significant better in Linagliptin group than in Glipizide group. Adverse events rate were significantly higher in Glipizide group than in Linagliptin group (18.57%vs 5.71% ,χ2 = 5.423 ,P= 0.020 ). Conclusion The efficacy of Linagliptin in combination with Metformin in newly diagnosed T2DM patients was similar with Glipizide plus Metformin. The β cell function improvement was better and APN level was higher after Linagliptin treatment.
