CT-guided percutaneous radiofrequency ablation for adrenocortical adenoma with Cushing's syndrome
10.3760/cma.j.issn.1674-6090.2015.06.002
- VernacularTitle:CT 引导下经皮射频消融治疗肾上腺皮质腺瘤库欣综合征
- Author:
Feng QU
;
Zhenlei ZHA
;
Kefeng ZHOU
;
Huibo LIAN
;
Gutian ZHANG
;
Wei WANG
;
Houjin LAN
;
Weidong GAN
;
Hongqian GUO
- Publication Type:Journal Article
- Keywords:
Adrenal adenoma;
Adrenocortical carcinoma;
Radiofrequency ablation;
CT-guided;
Cushing's syndrome
- From:
Chinese Journal of Endocrine Surgery
2015;(6):444-448
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the feasibility , safety, therapeutic effects and adverse reactions of CT-guided radiofrequency ablation (RFA)for adrenocortical adenoma with Cushing's syndrome.Methods From Jan.2009 to Dec.2013, 24 patients with 24 tumors diagnosed as adrenocortical adenoma with Cushing's syn-drome received CT-guided percutaneous RFA.The average tumor size was(2.1 ±0.7)cm(ranging from 1.1 to 3.9 cm) .RFA was performed under real-time computed tomography guidance .Technical success was defined as disappearance of tumor enhancement on contrast CT imaging 1 week after RFA .Clinical success was defined as improvement in serum cortisol, adreno-cortico-tropic-hormone(ACTH)and symptoms within the follow-up.Patho-logical diagnosis was acquired through the needle biopsy after RFA procedure .Results RFA was technically successful in all the 24 patients.No conversion occured.During operation, patients suffered blood pressure fluc-tuation but no one experienced a hypertensive crisis .Mild postoperative lumbar pain occurred in 6 patients . Tumor enhancement disappeared in CT scan .The mean follow-up was 18 months, ranging from 3 to 36 months. Both serum cortisol and ACTH basically returned to normal levels , and the symptoms related to Cushing's syn-drome gradually disappeared .No severe complications occurred during this procedure .Histopathology results showed all were adrenal cortical adenomas .No serious complication occurred to any patient during RFA .Conclu-sion CT-guided RFA for adrenocortical adenoma with Cushing's syndrome is a feasible , safe, effective and mini-mally invasive treatment with few complications .
