Mechanisms of action, resistance, and countermeasures of targeted therapy in advanced renal cell carcinoma
10.3969/j.issn.1000-8179.2015.24.210
- VernacularTitle:晚期肾癌靶向治疗的作用机制耐药机制与对策
- Author:
Xinwen KE
;
Zhiquan HU
- Publication Type:Journal Article
- Keywords:
advanced renal cell carcinoma;
targeted therapy;
action mechanism;
resistance mechanism;
countermeasures
- From:
Chinese Journal of Clinical Oncology
2015;(24):1159-1162
- CountryChina
- Language:Chinese
-
Abstract:
With the increasingly deepening research on the molecular regulatory mechanisms during the development and progres-sion of advanced renal cell carcinoma, the targeted therapy directed on the key proteinase/protein in the molecular signaling pathways significantly improves the management outcomes. However, the occurring resistance during therapy with targeted agents leads to de-creasing effects. The mechanisms of action, resistance, and countermeasures of targeted therapy in advanced renal cell carcinoma are simply reviewed.
