Efficacy of Acarbose in combination with life style modification on waist circumference in patients with impaired glucose tolerance
10.3969/j.issn.1006-6187.2015.12.011
- VernacularTitle:阿卡波糖联合调整生活方式改善糖调节受损人群腹围状况的研究
- Author:
Aidong SUN
;
Qingping JING
;
Shufen LI
- Publication Type:Journal Article
- Keywords:
Acarbose;
Impaired glucose tolerance (IGT);
Waist circumference (WC);
Islet β-cell function
- From:
Chinese Journal of Diabetes
2015;(12):1096-1098
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of acarbose on waist circumference (WC) in patients with IGR. Methods A total of 46 subjects with IGT (2 hPG>7.8 mmol/L) were selected in this study. All the subjects were given diet and exercise treatment for half a month and then treated with acarbose for 3 months in combination with life style modification. Self-paired method was adopted to compare islet βcell function and WC before and after the treatment. Results After acarbose treatment for 3 months ,islet βcell function were markedly improved. Insulin secretion of Fins and 2 hIns decreased ,early insulin secretion index (ΔI30/ΔG30 ) significantly increased ,and BMI and WC were reduced significantly (P<0.05) . Multiple regression analysis showed that there was correlation between WC and TG ,insulin resistance index (HOMA-IR) and islet β-cell function index (HOMA-β) (P< 0.05). Conclusion Acarbose in combination with life style modification can improve islet β-cell function in patients with IGR and reduce WC and abdominal fat accumulation as well.