Effect ofTan-Re-QingInjection on Perioperative Period of TNF-α, IL-6, IL-8 and IL-10 in Lung Cancer Patients Complicated with COPD
10.11842/wst.2015.10.023
- VernacularTitle:痰热清注射液对合并COPD肺癌患者围手术期TNF-α、IL-6、IL-8和IL-10的影响＊
- Author:
Guojiang XIONG
;
Junhong WU
;
Wei LV
;
Longhua SHANG
;
Hanpeng XIONG
;
Xiaoxiong LIU
;
Lihua WANG
- Publication Type:Journal Article
- Keywords:
Tan-Re-QingInjection;
lung cancer complicated with COPD;
inflammatory cytokine;
lung injury
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;(10):2083-2087
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to explore the possibility of reducing postoperative inflammatory response and lung injury degree by observing the effect ofTan-Re-Qing(TRQ) Injection on perioperative period of lung cancer patients complicated with chronic obstructive pulmonary disease (COPD). A total of 39 lung cancer cases complicated with COPD (phlegm-heat obstructing the lung) were randomly divided into the tested group of 18 cases and the control group of 21 cases. All patients underwent small incision surgery with video-assisted thoracoscopic surgery (VATS). The control group was treated with routine western medicine. TRQ injection was added in the tested group. On the preoperative 1D (T1), 1D after operation (T2), 3D after operation (T3), 7D after operation (T4), serum samples were collected for the determination of serum concentrations of TNF-α, IL-6, IL-8 and IL-10. At T1 and T2 time, there were no significant differences on levels of TNF-α, IL-6, IL-8 and IL-10 between two groups of patients (P > 0.05). At T3 time, levels of TNF-α, IL-6, IL-8 of the tested group were lower than that of the control group with statistical significance (P < 0.05). The level of IL-10 in the tested group was higher than that of the control group with statistical significance (P < 0.05). At T4 time, the levels of TNF-α, IL-6 and IL-8 of the tested group were lower than that of the control group with statistical significance (P < 0.05). The levels of TNF-α, IL-6 and IL-8 of both groups gradually declined at T3 and T4 time, compared with T2 time level with statistical significant (P < 0.05). It was concluded that TRQ injection reduced the releasing of inflammatory cytokines during perioperative period, increased levels of anti-inflammatory cytokine, thereby reducing the degree of inflammatory reaction and relieving lung injury for the protection of lung function of lung cancer patients complicated with COPD.
