Traditional Chinese Medicine Decoction Combined Bisphosphonates in Treatment of Bone Metastasis of Malignant Tumors：A Systematic Reviews and Meta-analysis
10.11842/wst.2015.10.033
- VernacularTitle:中药联合双磷酸盐治疗恶性肿瘤骨转移疗效的Meta分析＊
- Author:
Shengfei WANG
;
Qin WANG
;
Yanli FU
;
Lijing JIAO
;
Qing WANG
;
Ling XU
;
Jie ZHANG
- Publication Type:Journal Article
- Keywords:
Traditional Chinese medicine decoction;
bisphosphonates;
malignant tumor;
bone metastasis;
meta-analysis
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;(10):2136-2144
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to systematically appraise the effectiveness and safety of traditional Chinese medicine (TCM) decoction in combination with bisphosphonates in treatment of bone metastasis of malignant tumors. Related literatures were searched in the PubMed, Embase, CBM, CNKI and Cochrane Databases. The endpoints included cancer pain, activity of daily living, sclerotin reparation, KPS and adverse events. The Stata 11.0 software was used in the statistical analysis. The results showed that a total of 19 articles involving 1080 patients were included. It showed that TCM in combination with bisphosphonates can significantly relieve pain (RR=0.8079,95%CI =0.754-0.85,P <0.001), improve the activity of daily living (RR =0.787,95%CI =0.69-0.897,P <0.001), promote sclerotin reparation (RR =0.71,95%CI =0.52-0.96,P =0.026), and improve KPS (RR=0.7268,95%CI =0.61-0.85,0.58-0.81,P <0.001). It was concluded that TCM decoction in combination with bisphosphonates can significantly improve its therapeutic effect as well as improve the patients’ quality of life.
