Dynamic changes of C-reactive protein and cortisol in patients with sepsis and their relationship with prognosis
10.3969/j.issn.1006-5725.2015.23.030
- VernacularTitle:脓毒症患者血清C-反应蛋白、皮质醇的动态变化及其与预后的关系
- Author:
Jun LIU
;
Zeyu CHEN
;
Duanhui LIU
;
Xinbo HUANG
;
Yi MO
;
Zhenjie LIANG
;
Ziyang PAN
- Publication Type:Journal Article
- Keywords:
Sepsis;
C-reactive protein;
Cortisol
- From:
The Journal of Practical Medicine
2015;31(23):3909-3912
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the dynamic changes of plasma C-reactive protein (CRP) and cortisol (COR) and their clinical value in prognosis of patients with sepsis. Methods Daily CRP and COR detection was conducted to record the dynamic changes of CRP and COR for cases of sepsis patients in ICU then the rela-tionship between dynamic changes of serum CRP and COR and prognosis were analyzed. Results Serum CRP and COR levels of dead patients were significantly higher than those of survival patients after treatment (P <0.05). According to the difference of the dynamic changes of CRP and COR, the data were divided into typeⅠ:sustained elevated type , typeⅡ: up-and-down type , type Ⅲ: fluctuated type and type Ⅳ: normal or mild ele-vation type. The mortality of CRP typeⅠ patients was significantly higher than that of type Ⅱ and type Ⅳ(P <0.001). The mortality of COR typeⅠ and COR Ⅲ patients was significantly higher than that in COR Ⅱand COR Ⅳ (P < 0.001). Further analysis showed that the mortality of group with significant elevation of CRP and COR were obviously higher than that of group with significant increase of CRP or COR and that of group with no significant elevation of CRP and COR (P < 0.001); the mortality of group with significant increase of CRP or COR was also significantly higher than that of group with no significant elevation of CRP and COR (P < 0.001). Conclusions The dynamic changes of COR and CRP in patients with sepsis present certain regularity and monitor-ing the dynamic changes of the two provides accurate assessment of the prognosis of sepsis.
