Study on the cerebral protection of fasudil for hypoxic-ischemic cerebral damage of neonatal rats

VernacularTitle:法舒地尔对新生大鼠缺氧缺血性脑损伤的脑保护作用
Author: Bingsong WANG ; Zuo WANG ; Dong XU ; Jiayan PAN ; Yan YAN ; Shifa ZHANG ; Mingxiong ZHOU
Publication Type:Journal Article
Keywords: Hypoxic-ischemic cerebral damage; Fasudil; Neonatal rat; ROCK-2; α-SMA
From: The Journal of Practical Medicine 2015;31(23):3836-3839
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of the cerebral protection and possible mechanism of fasudil for hypoxic-ischemic cerebral damage (HIBD) in neonatal rats. Methods The HBID model was established, then the mice were randomly divided into different groups. The expressions ofα-SMA and ROCK-2 were detected in the newborn rats with ischemia. Results Compared with the model group, expressions of α-SMA, ROCK-2 decreased in each treatment group with significant differences (P < 0.05 or P < 0.01). Following with the increases of administration dose and the administration time, expressions of α-SMA, ROCK-2 decreased gradually with significant differences (P<0.05 or P<0.01). Conclusion Fasudil can reduce the expressions of α-SMA, ROCK-2 in the newborn mice with hypoxic-ischemic brain damage to attenuate the brain tissue hypoxic-ischemic injury. The protective effect on brain is significant by giving high-dose fasudil in the early neonatal rat HIBD (0 h).