Effect of interaction between ADIPOQ gene 11377C/G polymorphism and physical activity on metabolic syndrome in children
10.3969/j.issn.1006-5725.2015.23.011
- VernacularTitle:ADIPOQ基因11377C/G位点多态性与身体活动对儿童代谢综合征的影响
- Author:
Kaifeng WANG
;
Ping YE
;
Dan WANG
;
Liufeng WU
;
Weijia LIU
;
Qing CHEN
;
Jiandong LI
- Publication Type:Journal Article
- Keywords:
Metabolic syndrome;
Gene polymorphism;
Physical activity;
Interaction
- From:
The Journal of Practical Medicine
2015;31(23):3853-3856
- CountryChina
- Language:Chinese
-
Abstract:
Objectve To study the effect of interaction between ADIPOQ 11377C/G (rs266729) gene polymorphism and physical activity in metabolic syndrome in children. Methods We conducted a case-control study in 114 cases and 114 controls. The genotype of ADIPOQ 11377C/G had been detected in direct sequenc-ing. The effect of interaction between gene polymorphism and physical activity was evaluated by a crossover analysis. Results Efficient physical activity was a protective factor (OR = 0.14); there was interaction between inefficient physical activity and CC genotype of 11377C/G which was a risk factor for metabolic syndrome in children. Conclusion Efficient physical activity can reduce the risk of metabolic syndrome in children. There was interaction between 11377C/G (rs266729) polymorphism and physical activity.
