Relationship between C-peptide and artherosclerosis in lower extremity in patients with type 2 diabetes
10.3969/j.issn.1006-5725.2015.23.016
- VernacularTitle:血清C肽与2型糖尿病下肢动脉硬化的关系
- Author:
Qi CUI
;
Chunjie YANG
;
Guiwen CAO
;
Hong ZHOU
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes;
C-peptide;
Artherosclerosis of lower extremity
- From:
The Journal of Practical Medicine
2015;31(23):3869-3872
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between C-peptide and artherosclerosis in lower ex-tremity in patients with type 2 diabetes. Methods Two hundred and fourteen type 2 diabetic patients were included in this retrospective study. They were divided into two groups:type 2 diabetes with artherosclerosis in lower extremi-ty in 123 cases and type 2 diabetes without artherosclerosis in lower extremity in 91 cases. Their medical history and the laboratory data were collected such as fasting serum C-peptide levels and postprandial serum C-peptide levels of 1 hour, 2 hours and 3 hours, glycated hemoglobin (HbA1c) and so on. Results Compared with artherosclerosis group in lower extremity, the age, duration of diabetes, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), glycated hemoglobin and smoking rate were significantly higher in type 2 diabetes without artherosclero-sis in lower extremity (P < 0.05). However, the high density lipoprotein cholesterol (HDL-C) was much lower in the last group (P<0.05). There were no significant differences in the other indicators between the two groups (P>0.05). Logistic regression analysis showed that fasting and postprandial (1 hour, 2 hours and 3 hours)serum C-pep-tide levels were all negatively related to artherosclerosis in lower extremity (OR 0.524,P = 0; OR 0.440, P = 0;OR 0.688, P=0;OR 0.795, P=0). Conclusions Serum C-peptide level may be an independent associated fac-tor with artherosclerosis in lower extremity in type 2 diabetes.
