Endoscopic dilation combined with intramuscular injection of mitomycin C for benign esophageal strictures
10.3760/cma.j.issn.1007-5232.2015.12.012
- VernacularTitle:内镜下扩张联合注射丝裂霉素治疗食管良性狭窄的疗效评价
- Author:
Yin ZHANG
;
Li LIU
;
Min WANG
;
Jianping CHEN
;
Zhining FAN
;
Xiang WANG
- Publication Type:Journal Article
- Keywords:
Mitomycin;
Dexamethasone;
Endoscopic dilation;
Esophageal benign stricture
- From:
Chinese Journal of Digestive Endoscopy
2015;32(12):828-831
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and efficacy of an endoscopic dilation in association with the intramuscular injection of either mitomycin C for benign esophageal strictures. Methods A total of 89 patients with benign esophageal strictures were retrospectively divided into 3 groups, including 30 cases of dilation combined with mitomycin C injection (mitomycin C group) , 29 of dilation combined with dexamethasone injection (dexamethasone group) and 30 of dilation with saline injection (dilation group). The successful rate, complications and the clinical effect in the 3 groups were compared. Results The 89 patients all successfully received the procedure, with the endoscopic and clinical release. No massive hemorrhage occurred. In mitomycin C group, 1 case with major complication (perforation) and 7 minor complication occurred;9 and 7 cases with minor complication occurred in dexamethasone group and dilation group, respectively. There were no significant difference of the complications in the 3 groups (P<0. 05). The mean dysphagia-free period was 5. 25±1. 18 months in the mitomycin C group, 4. 46±1. 53 months in the dexamethasone group, and 3. 03±1. 62 months in the dilation group (P<0. 05). Conclusion Endo-scopic dilation with or without the intramuscular injection of either mitomycin C or dexamethasone are safe and effective. Dilation combined with drug injection may prolong the esophageal dysphagia-free period. Furthermore, mitomycin C injection may have the dominant effect.
