Stability of anticoagulant peptide Hirulog-S
10.7644/j.issn.1674-9960.2015.12.012
- VernacularTitle:抗凝血多肽Hirulog-S的稳定性研究
- Author:
Shuo YU
;
Huiqin GUO
;
Mingxin DONG
;
Qiuyun DAI
- Publication Type:Journal Article
- Keywords:
anticoagulant;
stearic acid modified peptide;
Hirulog-S;
stability;
chromatography;
high pressure liquid
- From:
Military Medical Sciences
2015;39(12):934-937
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the stability of anticoagulant peptide Hirulog-S and its lyophilized product, and to provide data on the storage conditions and clinical applications.Methods RP-HPLC was used to determine the content and the related substances of Hirulog-S and its lyophilized powder with influence factor test, accelerated test and long-term storage test.Results Light, temperature and humidity had no significant effect on the stability of Hirulog-S and its lyophilized powder in the influence factor test.The content and related substances of Hirulog-S and its lyophilized powder did not significantly change in the accelerated test ( 40℃, RH75%) and 24-month long-term storage test at room temperature and 4℃.Conclusion Hirulog-S and its lyophilized product are very stable, even after being stored at room temperature for two years.
