Correlation between TGF gene polymorphism and multiple myeloma
10.3969/j.issn.1673-4130.2015.24.019
- VernacularTitle:转化生长因子基因多态性与多发性骨髓瘤的相关性
- Author:
Fuqiu HAN
;
Guodong YANG
;
Shichao WANG
;
Hairong DONG
- Publication Type:Journal Article
- Keywords:
multiple myeloma;
single nucleotide polymorphism;
transforming growth factor gene
- From:
International Journal of Laboratory Medicine
2015;(24):3554-3555
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between transforming growth factor gene (TGF) single nucleotide poly‐morphism (SNP) and multiple myeloma (MM) .Methods The case control study was performed ,55 patients with MM and 55 healthy controls were selected .The genotype and allele detections were performed by adopting the polymerase chain reaction (PCR) and the ligase detection reaction (LDR) respectively .Then the sequencing based typing was further conducted .Results There were no statistically significant differences in the two loci genotype frequencies ,allele frequencies and genotype frequencies in joint hap‐loid typing between the MM group and the control group(P>0 .05) .Conclusion SNP of TGF gene has no obvious correlation with the occurrence of MM and subtypes.
