Mitochondrial calcium uniporter complex and regulation of their protein interaction
10.3969/j.issn.1000-4718.2015.12.031
- VernacularTitle:线粒体钙单向转运体及其蛋白相互作用的调控
- Author:
Bin XU
;
Yang LI
- Publication Type:Journal Article
- Keywords:
Mitochondria;
Calcium uniporter;
Calcium balance
- From:
Chinese Journal of Pathophysiology
2015;(12):2291-2295
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial calcium homeostasis plays a key role in maintaining various cellular characteristics and mediating cellular physiological function and pathological processes .Although it has long been known that mitochondria takes up Ca2+, the molecular identities of the channels and transporters involved in this process are revealed only recently . Here, we review the structure and function of the channel-forming subunit, mitochondrial calcium uniporter (MCU) and its regulators, which include MICU1, MICU2, and MCUR1.
