Progress of ELMO family on malignant tumor invasion and metastasis
10.3969/j.issn.1000-4718.2015.12.032
- VernacularTitle:ELMO 蛋白家族与恶性肿瘤侵袭转移关系的研究进展
- Author:
Chengming GUO
;
Huiyun PENG
;
Wen LUO
;
Qiongfang YU
;
Dian GAO
- Publication Type:Journal Article
- Keywords:
Invasion;
Metastasis;
Engulfment and cell mobility proteins;
Malignant tumor
- From:
Chinese Journal of Pathophysiology
2015;(12):2296-2300
- CountryChina
- Language:Chinese
-
Abstract:
It is one of the main characters of malignant tumors that malignant tumor cells invade surrounding tissues and metastasize to distant tissues .Multiple factors are involved in this complicated dynamic process .Metastasis is the major factor influencing recurrence and prognosis .Therefore, it is important to explore the mechanism of invasion and metastasis for reducing recurrence rate and mortality of malignant tumors .Engulfment and cell mobility ( ELMO) family is one kind of conserved protein in evolutional process .It includes 3 members, ELMO1, ELMO2 and ELMO3.The members of ELMO family play an important role in cell phagocytosis and cell migration , and they also have close correlation with ma-lignant tumor cell invasion and metastasis .In this paper , we review the progress of the relationship between ELMO family and malignant tumor invasion and metastasis .
