Research Progress of Genetics of Alzheimer's Disease (review)
10.3969/j.issn.1006-9771.2015.12.001
- VernacularTitle:阿尔茨海默病的基因组学研究进展
- Author:
Meiqin WANG
;
Kaibing YANG
;
Ran JI
;
Qinghua PANG
;
Dabao ZHANG
;
Min ZHANG
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
single nucleotide polymorphism;
pathway;
database;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2015;(12):1365-1369
- CountryChina
- Language:Chinese
-
Abstract:
Genetic factors play an important role in the development of Alzheimer's disease (AD). This article mainly introduced some genes, which have been reported in recent years, predisposing to different aspects of AD. The occurrence and progress of the late onset Al-zheimer's disease (LOAD) can be better understood through further study of the susceptibility loci, especially by using the pathway analysis, and the important hub genes can be found so as to provide targets for clinical prevention, diagnosis and treatment. Due to the dispersion of genetic variant information, it needs detailed literature, online search and some bioinformatics methods to analyze the causative genes and signaling pathways related to LOAD. 3 databases were took as recourses, and they were analyzed with multi-means and multi-ways of analy-sis and data mining methods, in order to provide theoretical basis for further study and clinical treatment of AD genetics.
