On mitochondrial quality control regulated by Bcl-2 family
10.3969/j.issn.1001-1978.2015.12.002
- VernacularTitle:Bcl-2家族对线粒体质量控制的调控研究
- Author:
Xiuyu SUN
;
Liya LIU
;
Youxi WU
;
Xiulan HUANG
- Publication Type:Journal Article
- Keywords:
Bcl-2 family proteins;
mitochondrial quality con-trol;
mitophagy;
apoptosis;
mitochondrial fission and fusion;
Bnip3;
PINK1 -Parkin pathway
- From:
Chinese Pharmacological Bulletin
2015;(12):1633-1636
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial quality control is the important mecha-nism that regulates the morphology,quantity and quality of mito-chondrial in cell to maintain cellular homeostasis and thus,cell survival and health.It has been revealed that members of Bcl-2 family are linked to mitochondrial function and integrity.Bcl-2 family proteins are the key regulators of mitochondrial quality control,participating in the signaling pathways regulating the
crosstalk between mitophagy and apoptosis,as well as mitochon-drial fission and fusion.This paper mainly reviews their impact on mitochondrial quality and the major signaling pathways regula-ted by Bcl-2 family proteins.
