Study on the protective effect in immunological liver injury in mice of Zhizi Baipi Soup and its disassembled prescription
10.3969/j.issn.1001-1978.2015.12.027
- VernacularTitle:栀子柏皮汤及含栀子配伍组对免疫性肝损伤小鼠的保护作用
- Author:
Yang YANG
;
Xiaoqin WU
;
Xiaofeng LI
;
Wanxia LI
;
Cheng HUANG
;
Jun LI
- Publication Type:Journal Article
- Keywords:
Zhizi Baipi Soup;
disassembled prescrip-tion containing Zhizi;
ConA;
immunological liver inju-ry;
NF-κB-p65;
NF-κB-p-p65
- From:
Chinese Pharmacological Bulletin
2015;(12):1764-1769
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of Zhizi Baipi soup and its disassembled prescription containing Zhizi on protecting concanavalin (ConA)-induced immuno-logical liver injury in mice and explore the possible protective mechanism.Methods The model of mouse immunological liver injury induced by (ConA,20 mg ·kg -1 )was used to observe the effects of Zhizi Baipi soup and its disassembled prescription containing Zhizi by gavage administration.Results Zhizi Baipi Soup and its disassembled prescription containing Zhizi were able to reduce the level of serum ALT,AST and MDA content,improve liver tissue SOD activity and reduce
the expression of NF-κB-p65 and NF-κB-p-p65,in which all parties of Zhizi Baipi Soup Group had best effect on immunological liver injury in mice.Conclu-sion Zhizi Baipi Soup and its disassembled prescrip-tion containing Zhizi have remarkably protective effect on ConA-induced immunological liver injury in mice, and the potential mechanism may be related to the reg-ulation of the immune response pathway.
