Research on progress on presbycusis based on cell apoptosis
10.3969/J.ISSN.1672-8270.2015.12.027
- VernacularTitle:基于细胞凋亡的老年性耳聋发病机制研究进展
- Author:
Xin ZHANG
;
Qiuying WU
;
Wangjiang WU
- Publication Type:Journal Article
- Keywords:
Presbycusis;
Apoptosis;
Caspase-3;
XIAP;
Sir2 T1
- From:
China Medical Equipment
2015;(12):84-86
- CountryChina
- Language:Chinese
-
Abstract:
Several proteins associated with apoptosis were analyzed to investigate the progress of presbycusis based on cell apoptosis. Four proteins of caspase-3, XIAP, Sir2 T1 and cytochrome C which were associated with apoptosis were selected. Influence and progress of four proteins on presbycusis were analyzed. Apoptosis is the key factor which causes presbycusis, including apoptosis of cochlear hair cells, cochlear spiral ganglion cells and primary auditory cortical neuron. There is a close relationship between the four proteins and apoptosis of hearing related cells. These four kinds of protein factors played a role in the progress of presbycusis and are expected to serve as a target for the treatment of presbycusis.
