Research progress of microtubule inhibitor-induced tumor cell mitotic catastrophe
10.3969/j.issn.1001-1978.2015.12.003
- VernacularTitle:微管抑制剂诱导肿瘤细胞有丝分裂灾难研究进展
- Author:
Xiang ZOU
;
Chao WANG
;
Zhongyuan QU
;
Yueni FANG
;
Jiejing SHENG
;
Yubin JI
- Publication Type:Journal Article
- Keywords:
microtubule inhibitor;
tubulin polymerization agent;
tubulin depolymerization agent;
mitotic catastrophe;
spindle as-sembly checkpoint;
molecular mechanism
- From:
Chinese Pharmacological Bulletin
2015;(12):1637-1640
- CountryChina
- Language:Chinese
-
Abstract:
Microtubule inhibitor has been a hot area of anticancer drugs research.Microtubule inhibitor exert an anti-tumor effect by promoting or inhibiting the microtubule aggregation to break the dynamic balance of microtubule,hindering the spindle forma-tion of tumor cells,and then blocking the process of cell divi-sion.Mitotic catastrophe is a cell death phenomenon that is caused by abnormal cell division and damage of spindle structure in cell mitosis phase.In recent years more and more attention has been paid to mitotic catastrophe cell death because it has
been confirmed clinically that microtubule inhibitors can induce mitotic catastrophe death of tumor cells.This paper reviews the latest research progress of microtubule inhibitors,and discusses the molecular mechanisms of mitotic catastrophe cell death tumor cells induced by microtubule inhibitors.
