The Role of JNK kinase in apoptosis and its relationship with cancer
10.3969/j.issn.1001-1978.2015.12.004
- VernacularTitle:JNK 激酶在细胞凋亡中的作用及其与癌症的关系
- Author:
Dongmei YU
;
Shu AN
;
Yang YANG
;
Ying LIU
;
Tianrui XU
;
Xiaoxi GUO
- Publication Type:Journal Article
- Keywords:
JNK kinase;
JNK1 /JNK2 /JNK3;
signaling path-way;
apoptosis mechanism;
cell apoptosis;
cancer
- From:
Chinese Pharmacological Bulletin
2015;(12):1641-1645
- CountryChina
- Language:Chinese
-
Abstract:
JNK is a key protein in the third stages of MAPK pro-tein kinase activation cascade,and is located in the key node of multiple signal transduction network.It plays a pivotal role in the cell proliferation,differentiation,apoptosis and some other important cell biological processes.Therefore it acts as an im-portant factor in regulating the development of some major human diseases,such as cancer.But the functional diversity and com-plexity of three JNK isoforms in different cell types make it diffi-
cult to develop anticancer drugs with JNK as a treatment target. In this review,we summarized the apoptotic signaling network of JNK and the regulation functions of JNK in cell apoptosis and proliferation.We also discuss the different functions of 3 JNK isoforms in human cancer.
